O'Keeffe's Working Hands Hand Cream – Fragrance-Free Skin Barrier for Allergy-Prone and Reactive Skin
O'Keeffe's Working Hands Hand Cream – Fragrance-Free Skin Barrier for Allergy-Prone and Reactive Skin
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Why you'll love it
- Clinically proven to instantly boost moisture and show visible results within days
- Hypoallergenic and unscented formula safe for diabetics and sensitive skin
- Non-greasy texture absorbs quickly without leaving residue on hands or surfaces
- Concentrated formula creates a lasting protective barrier that locks in moisture
- Trusted reputation as the #1 hand cream brand in America
- Convenient 7 oz tube format ideal for keeping at home for reliable daily supply
Perfect for
- Repairing extremely cracked, dry hands caused by manual labor or harsh weather exposure
- Daily post-handwashing moisturizing routine to prevent moisture loss
- Intensive overnight hand repair treatment applied at bedtime
- Post-bathing skin hydration to lock in moisture
- Diabetic-friendly hand care to prevent painful cracking and skin breakdown




Product Information
Get your hands back: O’Keeffe’s Working Hands is a concentrated moisturizing cream that heals, relieves, soothes and repairs extremely cracked, dry hands; From the #1 hand cream brand in America*
Guaranteed relief for extremely dry hands: A hand cream that creates a protective layer on the skin's surface, locking in moisture and keeping even the driest skin hydrated and healthy
Hardworking skincare: O'Keeffe's Working Hands dry hand cream provides an instant moisture boost to relieve your discomfort and repair your dry skin to be full, moisturized and nourished
Recommended use: For best results, apply after hand washing, after bathing, and at bedtime - these are the most effective times for moisturizing extremely dry hands and skin
Hypoallergenic: O'Keeffe's Working Hands is unscented, non-greasy and safe for people with diabetes; Our 7 ounce tube is perfect for a reliable at-home supply of comfort and moisture
O’Keeffe’s Working Hands Hand Cream is a concentrated, unscented dry hand repair cream that heals, relieves and repairs extremely dry, cracked hands. When used daily, O’Keeffe’s Working Hands Hand Cream is clinically proven to instantly boost moisture levels, help prevent further moisture loss, create a protective layer on the skin's surface that locks in moisture and keeps your skin hydrated, and make a difference you will feel within days. O’Keeffe’s offers a tube version of our moisturizing dry hand cream. Our tube formula offers the same results O’Keeffe’s jar users know and expect in the convenience of a tube! Whether you prefer a tube or jar, O’Keeffe’s Working Hands Hand Cream comes in both forms to provide relief. Click on the O'Keeffe's link at the top of this page to shop the O'Keeffe's Brand Store.
Items Details
Frequently Asked Questions
Is this hand cream safe for people with diabetes?
Yes. The formula is specifically designed to be safe for diabetics, helping to prevent the painful cracking and skin breakdown that can lead to more serious complications.
Will the unscented formula irritate sensitive or reactive skin?
No. It is hypoallergenic and fragrance-free, which makes it well suited for people with sensitive skin, allergies, or skin conditions that react to scented products.
Is it safe to use on elderly or thinning skin?
Yes. The gentle, hypoallergenic formula is appropriate for older adults, and the concentrated moisture barrier helps protect age-related dry skin from cracking and infection.
Can caregivers use it on someone else's hands without worry?
Yes. The safe, unscented, hypoallergenic formula is appropriate for caregiver use, whether assisting a child, an aging parent, or a patient with sensitive skin.
Does it help prevent skin breakdown that can lead to infection?
Yes. By maintaining the skin's moisture barrier and repairing cracks, the cream helps protect compromised skin from bacteria and other infection risks, which is especially important for diabetics and the elderly.
I need a hand cream I can trust for a diabetic family member. Is this the right one?
Yes. It is specifically formulated to be safe for diabetics and is widely recommended as a daily hand care staple to prevent painful cracking and skin complications.
Is this safe to use on hands that already have open cracks or splits?
Yes. The concentrated, gentle formula is designed to soothe and repair extremely cracked skin, though for deep or infected wounds you should consult a healthcare professional.
Will the cream cause any reaction if it gets near my eyes or mouth?
The formula is hypoallergenic and fragrance-free, making it gentle on skin, but like any hand cream it is intended for external use on the hands only. Avoid direct contact with eyes and mouth and rinse with water if accidental contact occurs.
How does this compare to a heavily perfumed drugstore hand cream for safety?
Unlike many perfumed drugstore creams that can irritate sensitive skin, this hypoallergenic, unscented formula is specifically designed to minimize the risk of allergic reactions and irritation.
Is it safe to use every day long-term?
Yes. The gentle, hypoallergenic formula is designed for daily, long-term use, which is exactly what makes it effective at preventing recurring dryness and cracking.
Can it be used in households with children or pets around?
Yes. The unscented, non-toxic formulation makes it appropriate for use in family households, though as with any personal care product, it should be stored out of reach of small children and pets.
I'm worried about chemicals. Is this formula clean and minimal?
Yes. The formula is intentionally simple, hypoallergenic, and unscented, which makes it a trusted choice for buyers who want a minimal-ingredient, low-irritant product.
What if I have a skin condition like eczema or psoriasis?
The hypoallergenic, fragrance-free formula is designed to minimize irritation, and many users with eczema or psoriasis find it helpful for daily moisture maintenance. For active flare-ups, consult your dermatologist.
Is there any risk of the cream interfering with blood sugar testing?
The non-greasy, fast-absorbing formula minimizes residue on fingertips, which helps support accurate fingerstick testing. Always wash and fully dry hands before testing per your healthcare provider's instructions.
I'm hesitant to try yet another hand cream. What if this one doesn't work for me?
The cream is clinically proven to boost moisture and is the trusted #1 hand cream brand in America, and the hypoallergenic, unscented formula minimizes the most common reasons hand creams fail for sensitive users.
Is this safe to use alongside prescription skin treatments?
The gentle, hypoallergenic formula is generally compatible with other skin treatments, but if you are using prescription topicals, consult your healthcare provider before adding any new product to your routine.
How do I use O'Keeffe's Working Hands Hand Cream for the best results?
Apply a small amount to clean, dry hands as needed throughout the day, and reapply after every handwashing. For an intensive overnight repair treatment, apply a generous layer before bed and allow it to absorb fully. For best results after bathing, apply within minutes of toweling off to lock in moisture.
How often should I apply it each day?
Most users see the best results by applying the cream at least three times per day, including once at bedtime, and always immediately after handwashing when moisture loss is highest.
Can I use it on areas other than my hands?
Yes. The concentrated, hypoallergenic formula can be used on feet, knees, elbows, and other small areas of dry, cracked skin, though it is specifically designed and tested for use on the hands.
Is it compatible with hand sanitizer and frequent handwashing?
Yes. The cream is specifically designed for people who wash or sanitize their hands frequently, and using it after each wash helps replenish the moisture lost from sanitizing and soap.
Will it work with the soap I already use?
Yes. The cream is compatible with virtually all standard hand soaps and sanitizers, and pairing it with a gentle cleanser will deliver the best moisture recovery results.
What comes in the box when I order it?
Your order includes one 7 oz tube of O'Keeffe's Working Hands Hand Cream. No additional accessories or tools are required, and the product is ready to use straight out of the package.
Is this product safe for daily long-term use?
Yes. The hypoallergenic, unscented formula is designed for daily, long-term use by adults, and it is safe for people with sensitive skin, diabetics, and older adults when used as directed.
Can it be used during pregnancy or while breastfeeding?
The formula is hypoallergenic and fragrance-free, but if you are pregnant or breastfeeding and have specific concerns about skincare ingredients, consult your healthcare provider before use.
What is the difference between a hand cream and a regular body lotion?
Hand creams are specifically formulated to be more concentrated and barrier-focused than body lotions, because hands are washed far more often and exposed to more friction, cold, and irritants. That is why a dedicated hand cream like this one is more effective at repairing dry, cracked hands than a general body lotion.

